01 - Preheat oven to 350°F. Grease and flour a 9x5-inch loaf pan or line with parchment paper.
02 - Whisk together flour, baking powder, baking soda, and salt in a medium bowl and set aside.
03 - In a large bowl, beat butter and sugar until light and fluffy, approximately 2 to 3 minutes.
04 - Incorporate eggs one at a time, beating after each addition, then stir in lemon zest and vanilla extract.
05 - In a small bowl, mix whole milk with fresh lemon juice.
06 - Add the dry mixture to the wet ingredients in three parts, alternating with the milk-lemon juice mixture, beginning and ending with the dry ingredients. Stir just until combined.
07 - Pour batter into the prepared loaf pan and smooth the top evenly.
08 - Bake for 45 to 55 minutes, or until a toothpick inserted in the center comes out clean.
09 - Let the loaf cool in the pan for 10 minutes before transferring to a wire rack to cool completely.
10 - Whisk powdered sugar with 2 tablespoons lemon juice until smooth; add more lemon juice if needed to achieve a pourable consistency.
11 - Drizzle glaze evenly over the cooled loaf and allow it to set prior to slicing.